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Some conditions that require precaution include: Diabetic Retinopathy: In clinical trials, it was observed that brand-name semaglutide can temporarily worsen eye problems in diabetic patients due to sudden hypoglycemia (drops in blood glucose levels), which can worsen diabetic retinopathy

Some patients continue with dose adjustments or hormonal support

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The severity is typically less dramatic than the 0.25 to 0.5 mg jump because the body has already developed some tolerance to GLP-1 receptor activation